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These results suggest that HIF-1-BNIP3/NIX-mediated mitophagy is enhanced in M9a+sh EPAS1 cells

These stemness-enhancing mechanisms converge on key survival pathwaysEGFR signaling activation via SPINK1 stabilization in HCC and mTORC1 complex maintenance in oral carcinomascreating a self-renewal-permissive niche that drives metastasis and therapeutic evasion [64]

Advani SM, Shi Q, Overman MJ, Loree JM, Lam M, Morris V, Shureiqi I, Kee B, Dasari A, Vilar E, Sarshekeh AM, Lin HK, Manuel S, Hamilton S, Raghav K, Maru D, Kopetz S , Wang XS

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